Cyrus Poonawalla Against Cocktail Vaccine; Says No Need to Mix Two Vaccines


Lokmanya Tilak award recipient Cyrus Poonawalla says he is not in favour of mixing two vaccines.

The chairman of the company, Serum Institute of India, manufactures the Covi- shield vaccine, believes that there is no need to combine two vaccines.

He feels that if the combination fails to work, a battle of blame will ensue, with one company accusing the other of inefficacy.  


While Cyrus Poonawalla is against mixing two vaccines, he encourages taking a third or “booster dose”.

He says that the antibodies go down after six months and thus advises people to for a third dose. The ideal duration between the two doses is two months, but the government increased the gap due to a shortage of vaccines.

He also states that people can opt for the other vaccine in case of an emergency or if a particular vaccine is not available at the second dose.  


The Serum Institute of India produces ten crore vaccines per month. The chairperson says this was possible due to speedy permissions from the government, advanced preparations and lakhs of investments.

Poonawalla said that the government was being over-ambitious by assuring 45 crore vaccine production by September.

However, with the vaccines from other companies, the immunization is likely to increase in the following months. He also criticizes the government for banning exports of vaccines.

The 150 countries dependent on SII for vaccines blame the company for backing out at a crucial time.  


 While the mixed vaccines have not been tested and trialled under required circumstances, it is likely to boost immunogenicity.

According to the researchers, it will assist in overcoming the challenges of vaccination shortages and eliminating reluctance about vaccines in people’s minds that could have its origin in programmatic ‘errors,’ especially in circumstances where different Covid-19 vaccines are employed. 


This study was based on an observation of 18 villagers in Uttar Pradesh who were mistakenly administered Covaxin as the second dose in May this year.

The residents of Siddharthnagar, a village in Uttar Pradesh, were inadvertently administered separate vaccines for the double dose.

This study found that immunization with a heterologous combination of vaccinations was safe and provided better immunogenicity than two doses of homologous vaccination with the same vaccine.

However, because the study is based on only 18 people who had mixed vaccination, it is still in its early stages, although evidence shows that heterologous vaccination results in a greater antibody response. 


WHO’s chief scientist, Dr Soumya Swaminanthan, claims it a dangerous trend as ample research proving its efficacy and adverse effects is unavailable.

Before any more recommendations can be made, WHO says it has to analyze the evidence in each of these vaccination combinations.

However, based on the basic principles of how vaccines work, WHO believes that the mix-and-match regimens are likely to work.

Because of the potential benefits of such an approach, vaccinations can be used with greater flexibility in response to supply fluctuations. 

Experts suggest heterologous methods could help elicit a mixed antibody and cell-mediated immune response against COVID-19. 

Heterologous vaccination techniques may lead to stronger, broader, and longer-lasting immunity. 

Aastha Khera
Aastha Khera
Aastha is a second-year student at Christ University, Bangalore pursuing a triple major in Journalism, psychology and English Literature. She views the field of journalism and psychology as a much-needed duty towards the society and literature as food for the soul. She also has her work published in two anthologies. You are most likely to find her scribbling in her diary at 3am next to a tub of ice cream or adoring the moon with all her heart. Aastha is just embarking on her journey as a writer and is more excited than ever.



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